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Article summary:

1. Tapping-mode AFM (TM-AFM) phase imaging can be used to study surface changes of nanoparticles under different conditions.

2. Condensed water can soften particle surfaces and increase tip-sample interaction, while organic coatings can provide a compliant surface with high viscosity.

3. It is important to describe the physical properties of a sample surface in order to understand the surface changes of nanosize particles based on TM-AFM phase images.

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