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Article summary:

1. SYMPLICITY HTN-3 trial showed the safety but not efficacy of renal artery denervation for treatment-resistant hypertension at 6 months follow-up.

2. The final report presents the 36-month follow-up results, which show that patients who received renal artery denervation had larger reductions in blood pressure and better blood pressure control compared with those who received sham control from 12 to 36 months after the procedure.

3. The study adds to the evidence supporting the safety of renal artery denervation up to 36 months after the procedure, with no evidence of late-emerging complications.

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