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局部麻醉诱导的神经毒性 - PMC
Source: ncbi.nlm.nih.gov
Article summary:
1. 本文总结了围手术期神经损伤的发生率、危险因素和机制，重点关注局部麻醉诱导的神经毒性。
2. 围手术期神经损伤可以由多种临床因素引起，包括手术过程中对神经的直接机械应力和局部麻醉剂的毒性。
3. 局部麻醉剂除了对止血系统和炎症反应有积极影响外，还表现出时间和剂量依赖性的毒性作用。具体的细胞机制可能涉及内在半胱天冬酶途径、PI3K途径和MAPK途径。
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