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Article summary:

1. Proanthocyanidins (PAs) can attenuate ferroptosis against Influenza A virus (IAV)-induced acute lung injury (ALI) in mice by reducing IFN-γ.

2. PAs protect against IAV-induced pneumonia through the TGF-β1 and its relative signaling pathway.

3. PAs effectively alleviate histopathological lung injury, reduce inflammatory cytokines and chemokines secretion, and prevent mouse airway inflammation in ALI.

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