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Article summary:

1. Dupilumab, a fully human anti-interleukin-4 receptor α monoclonal antibody, was found to be effective in reducing severe asthma exacerbations and improving lung function in patients with uncontrolled asthma.

2. The study involved 1902 patients aged 12 or older who were randomly assigned to receive either dupilumab or a placebo for 52 weeks. Patients who received dupilumab had significantly lower rates of severe asthma exacerbation than those who received placebo, as well as better lung function and asthma control.

3. Greater benefits were seen in patients with higher baseline levels of eosinophils, but hypereosinophilia was observed in some patients who received dupilumab.

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