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Article summary:
1. 3D organoid cultures can simulate the emergence of treatment-persistent residual tumors.
2. Treatment-persistent tumor cells have a diapause-like molecular adaptation with suppressed MYC activity and reduced apoptotic priming.
3. Inhibiting MYC activity or interfering with the diapause-like adaptation may be potential therapeutic strategies against chemotherapy-persistent tumor cells.
Article analysis:
The article is generally reliable and trustworthy, as it provides evidence for its claims in the form of clinical studies, single cell studies, and 3D organoid cultures. The article also presents both sides of the argument by exploring potential therapeutic strategies against chemotherapy-persistent tumor cells, such as inhibiting MYC activity or interfering with the diapause-like adaptation. However, there are some points that could be further explored in order to make the article more comprehensive and balanced. For example, while the article mentions that “hundreds of molecular datasets exist for treatment-naive or relapsed tumors”, it does not provide any evidence to support this claim or explore how these datasets might be used to inform potential treatments for chemotherapy-persistent tumors. Additionally, while the article discusses potential risks associated with inhibiting MYC activity or interfering with the diapause-like adaptation, it does not provide any evidence to support these claims or explore possible counterarguments. Finally, while the article mentions that “clinically relevant doses of cytotoxic agents nearly eradicated cancer cells within 4–6 days” in 2D cultures, it does not provide any evidence to support this claim or explore why this might be different in 3D organoids.