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1. MRI has allowed for longitudinal studies exploring brain changes across the entire life span, with several investigations of brain development in childhood and adolescence currently underway.

2. The review discusses commonly used MRI measures and current knowledge of brain development through longitudinal investigations, as well as the biological validity of interpretations derived from these investigations and methods to process, analyze, and model longitudinal changes in brain structure.

3. The benefits of longitudinal designs are discussed, and the hope is expressed that this review will stimulate further discussion amongst researchers regarding best practices in longitudinal studies of brain development.

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