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Article summary:

1. Androgens mediate a wide range of developmental and physiological responses, particularly in male sexual differentiation and pubertal maturation, maintenance of spermatogenesis, and regulation of male gonadotropins.

2. The main steroidal androgen, testosterone, mediates its biological effects mainly by binding to AR (Androgen Receptor), which is an androgen-induced transcription factor in the nuclear receptor superfamily.

3. The transcriptional activity of AR is regulated by coregulatory proteins, including coactivators with acetyltransferase activity such as CBP (CREB Binding Protein) and SRC1 (Steroid Receptor Coactivator-1), as well as co-repressors such as cyclind1, calrenetin, and HBO1.

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