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Article summary:

1. This study aimed to investigate the effects of macrophages on the corrosion of cobalt-chromium-molybdenum (CoCrMo) alloy in vitro.

2. The results showed that macrophages could induce corrosion on CoCrMo alloy surfaces, and that electrocautery damage did not increase this process.

3. The clinical significance of these findings should be further investigated to determine if this could explain a small number of poor total knee arthroplasty reported outcomes.

Article analysis:

The article is generally reliable and trustworthy, as it provides a detailed description of the research conducted and its results. The authors have provided sufficient evidence for their claims, including inductively coupled plasma spectrometry data and scanning electron microscopy images. Furthermore, the authors have discussed potential implications for clinical practice, which adds to the trustworthiness of the article.

However, there are some potential biases in the article that should be noted. Firstly, the study was conducted using murine macrophages rather than human cells, which may limit its applicability to humans. Secondly, only one type of metal alloy was tested in this study; thus, it is unclear whether similar results would be obtained with other alloys or metals used in orthopedic implants. Additionally, while the authors discuss possible implications for clinical practice based on their findings, they do not provide any recommendations or suggestions for how clinicians should act upon these findings. Finally, while the authors note that their findings may explain a small number of poor total knee arthroplasty reported outcomes, they do not explore any other potential causes or contributing factors to these outcomes.