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Article analysis:

The article "Striatal and hippocampal contributions to flexible navigation in rats and humans" by Christoffer J. Gahnstrom and Hugo J. Spiers provides a comprehensive review of the role of the dorsal striatum and hippocampus in flexible navigation. The authors argue that while the hippocampus has been established as playing a crucial role in flexible navigation, recent evidence suggests that the dorsal striatum may also play an important role in such goal-directed behavior in both rodents and humans.

The article provides a detailed overview of various studies that have investigated the neural responses during spatial navigation via a biophysically plausible framework explained by reinforcement learning models. The authors highlight the importance of exploring the interaction between cortical areas and both the dorsal striatum and hippocampus during flexible navigation.

One potential bias in this article is that it focuses primarily on the role of the dorsal striatum in flexible navigation, while downplaying its limitations compared to the hippocampus. While it is true that recent research has highlighted the importance of the dorsal striatum in response strategy navigation, it is important to note that this type of learning is not traditionally considered flexible because it is tied to specific features of the environment.

Another potential bias is that while the article acknowledges some limitations of biophysically plausible modeling, it does not explore alternative models or counterarguments to reinforce its claims. For example, while reinforcement learning models can capture one-shot learning, they lack a biological basis for an allocentric coordinate system receiving input from place cells.

Overall, this article provides valuable insights into current research on flexible navigation but could benefit from exploring alternative perspectives and acknowledging limitations more thoroughly.