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Article summary:

1. Acute-on-chronic liver failure (ACLF) is a clinical syndrome characterized by jaundice, hepatic encephalopathy, digestive tract symptoms, coagulation dysfunction, hepatorenal syndrome, and severe infection.

2. The prognosis evaluation of ACLF patients is complicated and there are differences under different factors. Liver transplantation is currently the most effective cure but difficult to implement in reality.

3. Traditional Chinese and Western medicine treatment have made progress in improving the prognosis of ACLF patients and are a key direction for future exploration.

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