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Article summary:

1. Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis due to the absence of targeted therapies.

2. Co-expression of androgen receptor (AR) and cathepsin D (Cath-D) in TNBC independently predicts worse overall survival, making it a potential target for combinatory therapy with androgen antagonists and anti-Cath-D human antibodies.

3. AR expression in TNBC is controversial in terms of its prognostic value, but previous studies have shown that AR-positive TNBC has poorer prognosis and higher risk of late relapse.

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