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Article summary:

1. Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis due to the absence of targeted therapies.

2. Co-expression of androgen receptor (AR) and cathepsin D (Cath-D) in TNBC independently predicts worse overall survival, making it a potential target for combinatory therapy with androgen antagonists and anti-Cath-D human antibodies.

3. AR expression in TNBC is controversial in terms of its prognostic value, but previous studies have shown that AR-positive TNBC has poorer prognosis and higher risk of late relapse.

Article analysis:

该文章是一项研究,旨在评估非转移性三阴性乳腺癌患者中雄激素受体(AR)和溶酶体蛋白酶D(Cath-D)共表达的频率及其预后价值。然而,该文章存在一些偏见和不足之处。

首先,该文章没有考虑到其他可能影响预后的因素,如年龄、肿瘤分级、淋巴结转移等。其次,该研究只涉及了147名患者,样本量较小,可能导致结果不够可靠。此外,该文章没有提供关于AR/Cath-D共表达与治疗反应之间关系的信息。

此外,在讨论中提出了一种组合治疗方案,即使用雄激素拮抗剂和抗Cath-D人源抗体进行治疗。然而,并没有提供足够的证据来支持这种治疗方案是否真正有效。

最后,在整篇文章中并未探讨任何可能存在的风险或负面影响。这可能会误导读者认为组合治疗是安全无害的。

总之,尽管该文章提供了有关AR/Cath-D共表达与预后之间关系的初步信息,但由于其存在的偏见和不足,需要更多的研究来证实这些结果,并确定最佳治疗方案。