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1. Immunotherapies use antibodies to alter immune responses, and developing assays to assess their functional and biological effects on target receptors is necessary.

2. Receptor Occupancy Assay (ROA) can be incorporated into high-parameter flow cytometry panels to evaluate receptor expression and drug occupancy on defined cell subsets, providing information related to functional effects and safety.

3. Designing, optimizing, and validating an ROA is crucial for improving dose selection, pharmacology monitoring, and safety in clinical settings. However, it can be challenging and lead to exaggerated pharmacology if not accurately developed. Improvements in understanding epitopes, binding, affinities, and pharmacological effects may lead to improved antibody drug targeting and receptor evaluation.

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