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1. Tanycytes, a specialized cell population in the median eminence of the hypothalamus, have been suggested to control the crossing of blood-borne substances from the periphery into the brain and function as chemosensors.

2. Tanycytes express thyroid hormone transporters and iodothyronine deiodinase type 2, indicating their involvement in neuroendocrine circuits.

3. Activation of the TRH receptor 1 in β-tanycytes leads to an increase in tanycyte endfoot size and upregulation of TRH-degrading ectoenzyme, which may block hormone secretion into portal blood vessels and regulate the hypothalamic-pituitary-thyroid axis.

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