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Article summary:

1. Psychiatric disorders have a high genetic correlation, but identifying differential genetic variations between them can shed light on their biological differences and guide personalized treatment.

2. A statistical framework was used to identify differential genetic markers covering 18 psychiatric disorders/traits and 26 comparisons based on GWAS summary statistics, with almost perfect genetic correlation to individual-level data analysis.

3. In-depth analysis revealed the genes, pathways, cell types, and tissues involved in differentiating the disorders, as well as the ability of polygenic scores to differentiate related disorders for potential clinical applications.

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