Full Picture

Extension usage examples:

Here's how our browser extension sees the article:
Appears moderately imbalanced

Article summary:

1. SARS-CoV-2 infection causes DNA damage and an altered DDR activation, leading to impaired S-phase progression, DNA damage accumulation, induction of inflammatory pathways, and establishment of cellular senescence.

2. The degradation of CHK1 by viral factors ORF6 and NSP13 through the proteasome and autophagy pathways respectively leads to loss of RRM2, a component of the RNR complex, causing dNTP shortage.

3. SARS-CoV-2 N-protein impairs 53BP1 recruitment at DSB by competing with dilncRNAs binding, ultimately hampering DNA repair.

Article analysis:



其次,文章中提到SARS-CoV-2 N蛋白与dilncRNAs竞争结合,从而干扰DNA修复。然而,该论断缺乏充分的证据支持,并且未探讨其他可能解释这种现象的机制。