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Article summary:

1. TRPV3 is a nonselective calcium-permeable cation channel activated by warm temperature, voltage, and certain chemicals, and is involved in various physiological and pathological functions.

2. Carvacrol, a natural monoterpenoid from plant oregano, specifically activates TRPV3 channel by targeting the channel S2-S3 linker.

3. Leu508 is the most critical residue within the binding pocket consisting of four residues (Ile505, Leu508, Arg509, and Asp512) for the activation of TRPV3 by carvacrol but not 2-APB. Carvacrol can function as a molecular tool in designing novel specific TRPV3 modulators for further understanding of TRPV3 channel pharmacology.

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