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Article summary:

1. MDA-5 protein is degraded in poliovirus-infected cells, which may be a mechanism to antagonize production of type I interferon in response to viral infection.

2. Sensing of RNA viruses occurs through recognition of viral components such as double-stranded RNA (dsRNA), which triggers the innate immune system to produce antiviral cytokines alpha interferon (IFN-α) and IFN-β.

3. RIG-I and MDA-5 are similar proteins that induce type I IFN synthesis through the same pathway, but they specialize in recognition of different viruses. MDA-5 is critical for detecting infection with encephalomyocarditis virus (EMCV) and picornaviruses.

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