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1. A randomized, controlled study was conducted on normal-weight participants to investigate the effects of habitual daily intake of a high-fat/high-sugar snack or a low-fat/low-sugar snack for 8 weeks in addition to their regular diet.

2. The high-fat/high-sugar intervention decreased the preference for low-fat food while increasing brain response to food and associative learning independent of food cues or reward.

3. These alterations were independent of changes in body weight and metabolic parameters, indicating a direct effect of high-fat, high-sugar foods on neurobehavioral adaptations that may increase the risk for overeating and weight gain.

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