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Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory - PubMed
Source: pubmed.ncbi.nlm.nih.gov
Article summary:
1. Astrocytic ApoE vectors microRNAs that silence genes involved in neuronal cholesterol biosynthesis, leading to accumulation of acetyl-CoA and promotion of histone acetylation and transcription in neurons.
2. This ApoE-mediated neuronal epigenetic mechanism enhances memory consolidation in mice by increasing H3K27ac enrichment in the promoters of multiple neuronal immediate early genes.
3. Human ApoE4 vectors lower levels of miRNAs than ApoE3, making it less capable of metabolic and epigenetic regulation in neurons.
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