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Article summary:

1. Electronic cigarettes (ECs) are gaining popularity as a less harmful alternative to conventional cigarettes among smokers, but there is concern about the potential long-term health effects of chronic exposure to their residual toxicological load.

2. Previous studies have shown no deterioration in lung function, airway responses, and respiratory symptoms in healthy smokers who switched to ECs for a year, but very little is known about the long-term health effects of vaping.

3. This study aimed to compare health outcomes between regular daily EC users who have never smoked and a reference group of never smokers and non-users of EC over a period of 3.5 years, including blood pressure, heart rate, body weight, lung function, respiratory symptoms, and exhaled biomarkers of airway inflammation. The results showed no significant differences between the two groups in terms of these health outcomes.

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