1. Disconnected pancreatic duct syndrome (DPDS) is a common complication of acute necrotizing pancreatitis that significantly complicates the management of pancreatic fluid collections (PFCs).
2. Endoscopic approach, including transpapillary and transmural drainage, has become the preferred treatment for PFC with DPDS over percutaneous drainage and surgery.
3. The diagnosis of DPDS can be established by imaging methods such as contrast-enhanced computed tomography, ERCP, magnetic resonance cholangiopancreatography (MRCP), and EUS. Secretin-enhanced MRCP is recommended as an appropriate diagnostic method in existing guidelines.