1. Mechanosensitive ion channels play important roles in physiological processes, but studying them is limited by the lack of effective instruments.
2. The combination of atomic force microscopy (AFM) and patch clamp has opened up a way to study MS ion channels, but there are problems with interference and complexity.
3. The development of a mechanostimulated patch-clamp system that integrates a custom-designed planar patch-clamp with a robot-assisted AFM on an inverted fluorescence microscope can overcome these problems and achieve automatic patching, exchanging intracellular solution, nano-scale manipulation, accurate positioning, diversified stimuli, friendly human-machine interaction, and simultaneous signal recording.
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