1. Adult neurogenesis plays a critical role in various conditions, including cognitive dysfunction, Alzheimer's disease (AD), and Parkinson's disease (PD). Factors such as genetics, age, physical activity, and CNS disorders can influence adult neurogenesis.
2. Neuroinflammation, triggered by insults or injuries to the CNS, can either promote or inhibit neurogenesis. Immune components such as activated glia, cytokines, chemokines, and reactive oxygen species regulate different stages of adult neurogenesis.
3. The review discusses the effects of neuroinflammation and neurogenesis in neurological disorders such as AD, PD, ischemic stroke (IS), seizure/epilepsy, traumatic brain injury (TBI), sleep deprivation, cognitive impairment, anxiety- and depressive-like behaviors. It also explores potential therapeutic candidates based on preclinical and clinical evidence.