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1. Colorectal cancer is a genetic and biological paradigm for the evolution of solid tumors, providing insights into early detection, risk stratification, prevention, and treatment principles.

2. Genetic alterations in colorectal cancer drive cancer cell biology properties and shape the heterotypic interactions across cells in the tumor microenvironment.

3. Research advances pertaining to the genetics and biology of colorectal cancer, emerging concepts gleaned from immune and single-cell profiling, and critical advances and remaining knowledge gaps influencing the development of effective therapies for this cancer that remains a major public health burden are detailed in this review.

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