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Article analysis:

The article is generally reliable, as it provides detailed information about the concept method developed for remotely controlling signal amplification in living cells at specific locations and times. The authors provide evidence for their claims, such as demonstrating mRNA spatial and temporal resolution amplification imaging with ultra-high in vitro and in vivo sensitivity as a concept validation. Furthermore, the authors provide clear explanations of their methods, which makes it easy to understand how they achieved their results.

However, there are some potential biases that should be noted. For example, the authors do not explore any counterarguments or present both sides equally when discussing their concept method. Additionally, there is no mention of possible risks associated with this method or its potential applications. Finally, while the authors provide evidence for their claims, they do not discuss any limitations or weaknesses of their approach that could be addressed in future research.