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Article summary:

1. Real-world evidence (RWE) is becoming increasingly important in healthcare research, as it provides insights into how treatments work in real-life settings.

2. However, the devil is in the detail when it comes to RWE studies, as they require careful consideration of study design, data sources, and analysis methods.

3. To ensure the validity and reliability of RWE studies, researchers should use established frameworks and templates, measure covariates appropriately, and tailor their approach to the specific research question at hand.

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