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Article analysis:

This article provides an interesting approach to detecting nitroreductase under hypoxic conditions using a cofactor-substrate-based supramolecular fluorescent probe. The authors provide evidence for the formation of the host–guest platform through UV/Vis titration, microcalorimetry titration, and docking calculations, as well as confirmation of its stability through MALDI-TOF MS. However, there are some potential biases that should be noted in this article. For example, the authors do not explore any counterarguments or present both sides equally when discussing their approach to detecting nitroreductase under hypoxic conditions. Additionally, they do not discuss any possible risks associated with their approach or provide evidence for their claims made throughout the article. Furthermore, there is no discussion of alternative approaches to detecting nitroreductase under hypoxic conditions that could be compared to this one. Finally, there is some promotional content in this article that could be seen as biased towards the authors’ approach to detecting nitroreductase under hypoxic conditions.