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Hantavirus infections - PubMed
Source: pubmed.ncbi.nlm.nih.gov
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Article summary:

1. Hantavirus infections have been increasing in both amplitude and magnitude globally, with several novel hantaviruses identified in various insectivore hosts.

2. Hantavirus infection can result in two clinical syndromes: haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), caused by Old World and New World hantaviruses respectively.

3. The pathogenesis of both HFRS and HCPS involves increased vascular permeability and acute thrombocytopenia, likely due to a complex multifactorial process that includes immune responses, platelet dysfunction, deregulation of endothelial cell barrier functions, and genetic predisposition related to HLA type. There is currently no effective treatment or vaccine approved for use in the USA and Europe, so public awareness and precautionary measures are crucial for minimizing the risk of hantavirus disease.

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