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Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis - PubMed
Source: pubmed.ncbi.nlm.nih.gov
Article summary:
1. Notch/RBP-J signaling downregulates lactate transporter MCT2 transcription via its downstream molecule Hes1, leading to reduced intracellular lactate levels and blunted granulocytic MDSC (G-MDSC) differentiation.
2. c-Jun is identified as a novel intracellular sensor of lactate in the study, which interacts with lactate to protect from FBW7 ubiquitin-ligase-mediated degradation.
3. The relationship between the Notch-MCT2/lactate-c-Jun axis in myeloid cells and tumorigenesis is confirmed in clinical lung cancer biopsies.
Article analysis:
The article is generally reliable and trustworthy, as it provides evidence for its claims through experiments conducted on mice models and clinical lung cancer biopsies. The authors also provide detailed information about their methods, such as liquid chromatography mass spectrometry (LCMS) and CRISPR Cas9 mediated gene disruption, which adds credibility to their findings. Furthermore, the authors have provided a comprehensive list of references that support their claims.
However, there are some potential biases that should be noted. For example, the authors do not explore any counterarguments or alternative explanations for their findings. Additionally, they do not discuss any possible risks associated with their findings or present both sides of the argument equally. Finally, there may be some promotional content in the article as it does not provide an unbiased view of the research topic but rather focuses on promoting the authors’ own findings.