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Article summary:
1. Liver injury (LI) can be caused by oxidative damage, apoptosis, disordered lipid metabolism, and mitochondrial dysfunction, with alcohol use being a major predisposing factor.
2. Citri Reticulatae Pericarpium (CRP), a traditional Chinese medicine, contains flavonoids and alkaloids that prevent or treat LI. CRP extract has excellent biological activity and is used to treat nausea, vomiting, and anemia.
3. Systems pharmacology approach was used to analyze the links between CRP and LI through in vitro experiments. The study elucidated the mechanisms of CRP in regulating bodily functions and balancing them by eliminating pathogenic factors and strengthening vital energy.
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