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1. TP53 gene mutations are common in cancer, and restoring the functionality of p53 has been a therapeutic strategy for decades.

2. Despite efforts to develop p53-based therapeutics, few have reached late-stage clinical trials and none have been approved in the USA or Europe.

3. Promising approaches towards p53-based therapy include small molecules that protect p53 from negative regulators or restore mutant p53 functionality, tailored drugs for specific types of p53 mutants, gene therapy strategies, and immunotherapy approaches. However, challenges remain in clinical development.

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