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Role of platelets and platelet receptors in cancer metastasis | Journal of Hematology & Oncology | Full Text
Source: jhoonline.biomedcentral.com
Article summary:
1. Platelets play a crucial role in the successful hematogenous metastatic dissemination of tumor cells.
2. Platelets protect tumor cells from shear forces and assault of NK cells, recruit other cells, and mediate an arrest of the tumor cell platelet embolus at the vascular wall.
3. This review focuses on platelet adhesion receptors and their role in metastasis, particularly immunoreceptor tyrosine-based activation motif (ITAM) and hemi ITAM (hemITAM) comprising receptors such as glycoprotein VI (GPVI), FcγRIIa, and C-type lectin-like-2 receptor (CLEC-2).
Article analysis:
The article is generally reliable and trustworthy. It provides a comprehensive overview of the current literature on platelet-mediated effects in cancer metastasis, with particular focus on platelet adhesion receptors and their role in metastasis. The article is well researched and supported by evidence from previous studies. It also provides detailed information about the mechanisms involved in platelet-mediated effects in cancer metastasis. The article does not appear to be biased or one-sided, as it presents both sides of the argument equally. Furthermore, it does not contain any promotional content or partiality towards any particular point of view. The article also mentions potential risks associated with platelet-mediated effects in cancer metastasis, which is commendable. All in all, this article is reliable and trustworthy source of information about the role of platelets and platelet receptors in cancer metastasis.