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Hepatic hormone FGF21 and its analogues in clinical trials - PMC
Source: ncbi.nlm.nih.gov
Article summary:
1. FGF21 is a metabolic hormone produced mainly in the liver that plays an important role in regulating glucose and lipid homeostasis.
2. Clinical trials have been conducted to develop FGF21 derivatives or specific FGF21 receptor agonists as therapeutic agents for various metabolic disorders.
3. The article reviews the gene and protein structures of FGF21, its expression pattern, cellular signaling cascades that mediate FGF21 production and function, and clinical trials utilizing four FGF21 analogues.
Article analysis:
The article provides a comprehensive overview of the structure, expression pattern, cellular signaling cascades, and clinical trials involving FGF21 analogues. It is well-researched and supported by evidence from multiple sources such as National Center for Biotechnology Information (NCBI), Nishimura et al., etc. The article does not appear to be biased or one-sided in its reporting; it presents both sides of the argument equally without any promotional content or partiality. Furthermore, possible risks associated with using FGF21 analogues are noted throughout the article.
However, there are some missing points of consideration that could have been explored further such as potential side effects of using FGF21 analogues in clinical trials, long-term effects of using these drugs, etc. Additionally, there is no mention of unexplored counterarguments which could have provided a more balanced view on the topic.