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Article summary:

1. RBF-2, a factor composed of USF-1/USF-2 heterodimer and TFII-I, regulates HIV-1 transcription in T cells in response to T cell receptor engagement and is also required for repression of viral expression in unstimulated cells.

2. The HIV-1 long terminal repeat (LTR) is stringently controlled by T cell activation signals and binds a variety of transcription factors whose activities are regulated downstream of the T cell receptor.

3. Repression of proviral transcription in resting T cells likely involves repressive chromatin, and the LTR has phased nucleosomes positioned immediately downstream of the transcriptional start site and at approximately 140 nucleotides upstream.

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