1. Cellular senescence is a process that limits the number of times a cell can divide and is thought to contribute to organismic aging.
2. Senescent cells accumulate with age in human skin, and express genes that have long-range, pleiotropic effects such as degradative enzymes, growth factors, and inflammatory cytokines.
3. Senescent cells may compromise skin function and integrity, as well as contribute to the rise in cancer that occurs with age.
The article is generally reliable and trustworthy. It provides an overview of the role of cellular senescence in skin aging, citing relevant research studies to support its claims. The article does not appear to be biased or one-sided; it presents both sides of the argument fairly and objectively. Furthermore, it does not contain any promotional content or partiality towards any particular viewpoint.
The article does not appear to be missing any points of consideration or evidence for its claims; all claims are supported by relevant research studies cited throughout the text. Additionally, possible risks associated with cellular senescence are noted in the text.
The only potential issue with the article is that it does not explore counterarguments or alternative viewpoints on the topic; however, this is understandable given that it is a review article rather than an opinion piece or debate paper.