1. Konjac glucomannan (KGM) treatment effectively relieves constipation symptoms in mice: The study found that mice treated with KGM showed improvements in their physiological state, fecal character, small intestinal propulsive rate, gastric emptying rate, and various biochemical markers associated with constipation.
2. KGM regulates the diversity of gastrointestinal microbiota: The intervention of KGM in the diets of constipated mice led to changes in the microbiota profile. Specifically, it reduced the diversity of stomach and small intestine microbiota while increasing it in the large intestine. These changes brought the microbiota composition closer to that of a normal mouse group.
3. Specific bacteria are affected by KGM intervention: The study identified specific changes in bacterial species such as Lactobacillus, Bifidobacterium, and Allobaculum spp after KGM treatment. These findings suggest that KGM may regulate constipation through its effects on these bacteria.
Overall, this study highlights the potential of KGM as a therapeutic option for constipation and provides insights into its mechanisms of action involving gastrointestinal microbiota regulation.