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Article summary:
1. 基孔肯雅病毒（CHIKV）的nsP2、E2和E1基因强烈拮抗干扰素-β信号通路，抑制IFN-β启动子的激活。
2. CHIKV感染引起多种症状，包括头痛、发烧、关节和肌肉疼痛等。
3. 揭示CHIKV介导的IFN-β途径抑制的机制有助于开发针对该病毒的特异性治疗方法和疫苗。
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