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Appears moderately imbalanced

Article summary:

1. p53 binding to response elements (REs) is highly variable due to changes in direct and indirect readouts.

2. Hemi-specific binding is more prevalent in p53 REs than previously thought, and sequences flanking the REs modulate p53 binding and activity.

3. The arrangement of p53 half-sites within its REs has been fine-tuned by selection pressure to optimize and regulate the response levels from p53 REs, with directionality encoded in the structural properties of the REs.

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