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Article summary:
1. Vascular endothelial growth factor inhibitors (VEGFI) can cause a substantial rise in blood pressure (BP) during treatment, which may require antihypertensive drugs or even discontinuation of treatment.
2. Independent risk factors for developing a substantial BP rise during VEGFI therapy include pazopanib, normotension at baseline, and decreased kidney function.
3. Both calcium channel blockers and renin-angiotensin system inhibitors are effective options for lowering BP during VEGFI therapy, but careful monitoring is essential and choice of antihypertensive therapy should be based on patient-specific characteristics.
Article analysis:
该文章是一项临床队列研究，旨在探讨血管内皮生长因子抑制剂（VEGFI）治疗期间血压升高的治疗和影响。文章提供了一些有用的信息，但也存在一些潜在的偏见和缺陷。
首先，文章没有明确说明其来源和资助机构。这可能会引起读者对作者或机构的偏见，并影响对结果的信任度。
其次，文章只涉及单一药物pazopanib，而未考虑其他VEGFI药物。这可能导致结论不具有普适性，并忽略了其他药物可能产生的不同效应。
此外，文章声称BP升高与肾细胞癌患者总体生存率改善有关，但未提供足够的证据支持该主张。此类主张需要更多的研究来验证其有效性。
最后，文章没有充分探讨风险管理方面的问题。例如，在使用抗高血压药物时可能出现副作用或相互作用等问题。此外，该文也没有平等地呈现双方观点，并可能存在宣传内容。
综上所述，该文提供了一些有用信息，但也存在潜在偏见和缺陷。读者应该谨慎对待其结论，并寻找更多的证据来支持或反驳其主张。
Topics for further research:
Source and funding of the study
Consideration of other VEGFI drugs
Evidence supporting the claim of improved overall survival with BP elevation
Risk management issues with the use of antihypertensive drugs
Balanced presentation of both sides of the argument
Need for further research to support or refute the claims made in the article