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Article summary:

1. Sepsis-induced liver injury is a significant predictor of death in critical care units, and there is evidence of close interaction between the gut and the liver.

2. Disruption of the intestinal barrier and dysbiosis of gut microbiota during sepsis lead to the translocation of harmful molecules into the liver and systemic circulation.

3. The liver plays a crucial role in regulating immune defense during systemic infections, but overwhelming inflammation can impair its function, leading to further damage to the gut barrier and dysbiosis of gut microbiota. Therefore, targeting the interaction between the gut and liver may have therapeutic potential in sepsis treatment.

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