1. Piezo1 and Piezo2 are two proteins that have been identified as essential components of distinct mechanically activated cation channels.
2. These proteins are found in a variety of organisms, including vertebrates, invertebrates, plants, and protozoa.
3. Overexpression of mouse Piezo1 or Piezo2 induced two kinetically distinct MA currents, and knockdown of Piezo2 in dorsal root ganglia neurons specifically reduced rapidly adapting MA currents.
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