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Slow TCA flux and ATP production in primary solid tumours but not metastases - PubMed
Source: pubmed.ncbi.nlm.nih.gov
Article summary:
1. Tissues derive ATP from two pathways-glycolysis and the tricarboxylic acid (TCA) cycle coupled to the electron transport chain.
2. TCA cycle flux is suppressed in all five primary solid tumour models examined and is increased in lung metastases of breast cancer relative to primary orthotopic tumours.
3. Instead of being hypermetabolic, as commonly assumed, solid tumours generally produce ATP at a slower than normal rate.
Article analysis:
The article is overall reliable and trustworthy, as it provides evidence for its claims through experiments conducted on mouse tissues, Kras-mutant solid tumours, metastases and leukaemia. The authors also provide an explanation for their findings by proposing that cancer cells shed energetically expensive tissue-specific functions to enable uncontrolled growth despite a limited ability to produce ATP.
However, there are some potential biases in the article that should be noted. For example, the authors do not explore any counterarguments or present both sides equally when discussing their findings. Additionally, they do not mention any possible risks associated with their experiments or provide evidence for some of their claims made throughout the article. Furthermore, there is a lack of detail regarding the methodology used in their experiments which could lead to potential inaccuracies in their results. Finally, there is a lack of discussion regarding how these findings can be applied to clinical settings which could limit its usefulness for medical practitioners.