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1. Researchers have developed a non-invasive urine DNA methylation assay, called utMeMA, for the early detection and recurrence monitoring of bladder cancer.

2. The assay uses 26 BCa-specific methylation markers to build a diagnostic model that achieved high accuracy, sensitivity, and specificity in both retrospective and prospective cohorts.

3. The utMeMA-based assay showed improved sensitivity over traditional methods like urine cytology and FISH, especially in detecting early-stage, minimal, residual, and recurrent tumors. It may reduce the need for cystoscopy and blind second surgery.

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