1. Immunity-and-matrix-regulatory cells (IMRCs) derived from human embryonic stem cells have strong immunomodulatory and pro-regenerative potential, making them a promising candidate for meniscus injury repair.
2. IMRCs demonstrated stronger regenerative effects compared to umbilical cord mesenchymal stem cells when stimulated by synovial fluid from patients with meniscus injury.
3. In a phase I clinical trial, intra-articular injection of IMRCs in patients with meniscus injury was found to be safe and showed effective results in meniscus repair as observed through magnetic resonance imaging (MRI).