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1. Drug-resistant cancer is a major challenge in cancer treatment due to abnormal metabolism and reactive oxygen species (ROS) leading to therapeutic resistance.

2. Metal-organic framework (MOF)-based carbonized nanozymes have potential for ROS-mediated tumor therapy applications, but their catalytic performance is limited by micropore shrinkage and skeleton collapse.

3. A flower-like nanozyme with a highly porous carbon matrix was developed to induce a robust oxidative storm against drug-resistant cancer by increasing the 3D accessibility of active sites and shortening the distance between catalysts and biomolecules, resulting in cell re-sensitization and boosted inhibition of tumors.

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