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Article analysis:

The article is generally reliable and trustworthy due to its use of scientific evidence from peer-reviewed journals such as Adv Exp Med Biol., BMB Rep., Proc Natl Acad Sci U S A., Int J Mol Sci., Cell Transplant., and Iscience. The article also provides a comprehensive overview of the current understanding of pluripotent stem cell heterogeneity, including its causes, effects, and potential solutions for improving reproducibility of research.

However, there are some potential biases that should be noted. For example, the article does not explore any counterarguments or alternative perspectives on the topic. Additionally, it does not provide any information about possible risks associated with using pluripotent stem cells in research or clinical applications. Furthermore, the article does not present both sides of the issue equally; instead it focuses primarily on the positive aspects of using pluripotent stem cells without providing an equal amount of information about potential drawbacks or limitations. Finally, there is a lack of detail regarding specific methods for detecting, reducing, and controlling heterogeneity in experiments involving human PSCs; this could lead readers to believe that these methods are already well established when they may still require further development before they can be used effectively in practice.