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1. Chemotherapy drugs have poor selectivity and often result in severe adverse effects, while resistance to chemotherapy occurs in certain cancer cell lines.

2. Enzymatic nanoreactors based on metal-organic frameworks (MOFs) can be potent prodrug activators, with encapsulated enzymes showing enhanced stability and protection from proteolytic degradation.

3. The use of enzyme-MOF nanoreactors for tumor-specific prodrug activation led to significant cytotoxicity in drug-resistant cancer cells and tumor regression, with the mechanism involving the activation of nontoxic prodrug paracetamol by tyrosinase.

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