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Article summary:

1. Ferroptosis is a form of regulated necrotic cell death characterized by iron-dependent, lipid peroxidation-driven membrane destruction. It can be inhibited by glutathione peroxidase 4.

2. The kidney is particularly susceptible to redox imbalance, and growing evidence suggests that ferroptosis may play a role in acute kidney injury and chronic kidney disease.

3. Further research is needed to better understand the triggers, execution, and spreading mechanisms of ferroptosis in order to develop targeted therapeutic strategies for kidney disease.

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