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Article summary:
1. Dabigatran and conventional treatment (warfarin) were compared in patients with atrial fibrillation and left-sided valvular heart disease.
2. The primary end point was the occurrence of clinical stroke or a new brain lesion on 1-year follow-up brain magnetic resonance imaging.
3. The incidence rate of the primary end point did not significantly differ between groups, suggesting that dabigatran could be a reasonable alternative to warfarin in these patients.
Article analysis:
The article is generally reliable and trustworthy, as it provides evidence from multiple studies to support its claims. It also presents both sides of the argument fairly, noting potential risks associated with dabigatran treatment and providing evidence for why it may be a reasonable alternative to warfarin in certain cases. However, there are some potential biases that should be noted. For example, the study only included patients with left-sided valvular heart disease, so the results may not be applicable to other types of AF patients. Additionally, the study was relatively small in size and only followed up for one year; thus, further research is needed to confirm its findings over a longer period of time. Finally, while the article does mention potential risks associated with dabigatran treatment, it does not provide any detailed information about them or how they compare to those associated with warfarin treatment.